A Multivariate Analytic Approach to the Differential Diagnosis of Apraxia of Speech Purpose Apraxia of speech (AOS) is a consequence of stroke that frequently co-occurs with aphasia. Its study is limited by difficulties with its perceptual evaluation and dissociation from co-occurring impairments. This study examined the classification accuracy of several acoustic measures for the differential diagnosis of AOS in a sample of ... Research Article
Newly Published
Research Article  |   November 27, 2017
A Multivariate Analytic Approach to the Differential Diagnosis of Apraxia of Speech
 
Author Affiliations & Notes
  • Alexandra Basilakos
    Department of Communication Sciences & Disorders, University of South Carolina, Columbia
  • Grigori Yourganov
    Department of Psychology, University of South Carolina, Columbia
  • Dirk-Bart den Ouden
    Department of Communication Sciences & Disorders, University of South Carolina, Columbia
  • Daniel Fogerty
    Department of Communication Sciences & Disorders, University of South Carolina, Columbia
  • Chris Rorden
    Department of Psychology, University of South Carolina, Columbia
    McCausland Center for Brain Imaging, University of South Carolina, Columbia
  • Lynda Feenaughty
    Department of Communication Sciences & Disorders, University of South Carolina, Columbia
    Department of Neurology, Medical University of South Carolina, Charleston
  • Julius Fridriksson
    Department of Communication Sciences & Disorders, University of South Carolina, Columbia
    McCausland Center for Brain Imaging, University of South Carolina, Columbia
  • Disclosure: The authors have declared that no competing interests existed at the time of publication.
    Disclosure: The authors have declared that no competing interests existed at the time of publication. ×
  • Correspondence to Alexandra Basilakos: basilaka@mailbox.sc.edu
  • Editor: Julie Liss
    Editor: Julie Liss×
  • Associate Editor: Tanya Eadie
    Associate Editor: Tanya Eadie×
Article Information
Speech, Voice & Prosodic Disorders / Apraxia of Speech & Childhood Apraxia of Speech / Language Disorders / Aphasia / Newly Published / Research Article
Research Article   |   November 27, 2017
A Multivariate Analytic Approach to the Differential Diagnosis of Apraxia of Speech
Journal of Speech, Language, and Hearing Research, Newly Published. doi:10.1044/2017_JSLHR-S-16-0443
History: Received December 2, 2016 , Revised May 10, 2017 , Accepted July 19, 2017
 
Journal of Speech, Language, and Hearing Research, Newly Published. doi:10.1044/2017_JSLHR-S-16-0443
History: Received December 2, 2016; Revised May 10, 2017; Accepted July 19, 2017

Purpose Apraxia of speech (AOS) is a consequence of stroke that frequently co-occurs with aphasia. Its study is limited by difficulties with its perceptual evaluation and dissociation from co-occurring impairments. This study examined the classification accuracy of several acoustic measures for the differential diagnosis of AOS in a sample of stroke survivors.

Method Fifty-seven individuals were included (mean age = 60.8 ± 10.4 years; 21 women, 36 men; mean months poststroke = 54.7 ± 46). Participants were grouped on the basis of speech/language testing as follows: AOS-Aphasia (n = 20), Aphasia Only (n = 24), and Stroke Control (n = 13). Normalized Pairwise Variability Index, proportion of distortion errors, voice onset time variability, and amplitude envelope modulation spectrum variables were obtained from connected speech samples. Measures were analyzed for group differences and entered into a linear discriminant analysis to predict diagnostic classification.

Results Out-of-sample classification accuracy of all measures was over 90%. The envelope modulation spectrum variables had the greatest impact on classification when all measures were analyzed together.

Conclusions This study contributes to efforts to identify objective acoustic measures that can facilitate the differential diagnosis of AOS. Results suggest that further study of these measures is warranted to determine the best predictors of AOS diagnosis.

Supplemental Materials https://doi.org/10.23641/asha.5611309

Acknowledgments
This work was supported by two grants from the National Institutes of Health National Institute on Deafness and Other Communication Disorders (DC008355 and DC009571) to Julius Fridriksson.
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