Examining a New Method to Studying Velopharyngeal Structures in a Child With 22q11.2 Deletion Syndrome Purpose To date, no studies have imaged the velopharynx in children with 22q11.2 deletion syndrome (22q11.2 DS) without the use of sedation. Dysmorphology in velopharyngeal structures has been shown to have significant negative implications on speech among these individuals. This single case study was designed to assess the feasibility of ... Research Note
Research Note  |   April 14, 2017
Examining a New Method to Studying Velopharyngeal Structures in a Child With 22q11.2 Deletion Syndrome
 
Author Affiliations & Notes
  • Lakshmi Kollara
    Department of Communication Sciences and Disorders, East Carolina University, Greenville, NC
  • Graham Schenck
    Department of Communication Sciences and Disorders, East Carolina University, Greenville, NC
  • Michael Jaskolka
    Cleft and Craniomaxillofacial Surgery, New Hanover Regional Medical Center, Wilmington, NC
  • Jamie L. Perry
    Department of Communication Sciences and Disorders, East Carolina University, Greenville, NC
  • Disclosure: The authors have declared that no competing interests existed at the time of publication.
    Disclosure: The authors have declared that no competing interests existed at the time of publication. ×
  • Correspondence to Lakshmi Kollara: kollarasunill16@ecu.edu
  • Editor: Julie Liss
    Editor: Julie Liss×
  • Associate Editor: Jack Jiang
    Associate Editor: Jack Jiang×
Article Information
Speech, Voice & Prosodic Disorders / Special Populations / Genetic & Congenital Disorders / Speech, Voice & Prosody / Speech / Research Notes
Research Note   |   April 14, 2017
Examining a New Method to Studying Velopharyngeal Structures in a Child With 22q11.2 Deletion Syndrome
Journal of Speech, Language, and Hearing Research, April 2017, Vol. 60, 892-896. doi:10.1044/2016_JSLHR-S-16-0084
History: Received March 2, 2016 , Revised August 16, 2016 , Accepted October 21, 2016
 
Journal of Speech, Language, and Hearing Research, April 2017, Vol. 60, 892-896. doi:10.1044/2016_JSLHR-S-16-0084
History: Received March 2, 2016; Revised August 16, 2016; Accepted October 21, 2016

Purpose To date, no studies have imaged the velopharynx in children with 22q11.2 deletion syndrome (22q11.2 DS) without the use of sedation. Dysmorphology in velopharyngeal structures has been shown to have significant negative implications on speech among these individuals. This single case study was designed to assess the feasibility of a child-friendly magnetic resonance imaging (MRI) scanning protocol in this clinically challenging population and to determine the utility of this MRI protocol for future work in this area.

Method One 6-year-old White girl diagnosed with 22q11.2 DS was imaged using a child-friendly, nonsedated MRI protocol. Quantitative and qualitative measures of the velopharyngeal area and associated structures were evaluated, and comparisons were made to age-matched control subjects with normal velopharyngeal anatomy.

Results MRI data were successfully obtained using the child-friendly scanning protocol in the subject in the present study. Quantitative and qualitative differences of the levator muscle and associated velopharyngeal structures were noted. Using these MRI and structural analyses methods, insights related to muscle morphology can be obtained and considered as part of the research and clinical examination of children with 22q11.2 DS.

Conclusion The imaging protocol described in this study presents an effective means to counteract difficulties in imaging young children.

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