A Diagnostic Marker to Discriminate Childhood Apraxia of Speech From Speech Delay: II. Validity Studies of the Pause Marker Purpose The purpose of this 2nd article in this supplement is to report validity support findings for the Pause Marker (PM), a proposed single-sign diagnostic marker of childhood apraxia of speech (CAS). Method PM scores and additional perceptual and acoustic measures were obtained from 296 participants in cohorts ... Supplement Article
Supplement Article  |   April 14, 2017
A Diagnostic Marker to Discriminate Childhood Apraxia of Speech From Speech Delay: II. Validity Studies of the Pause Marker
 
Author Affiliations & Notes
  • Lawrence D. Shriberg
    Waisman Center, University of Wisconsin–Madison
  • Edythe A. Strand
    Department of Neurology, Mayo Clinic, Rochester, MN
  • Marios Fourakis
    Waisman Center, University of Wisconsin–Madison
  • Kathy J. Jakielski
    Department of Communication Sciences and Disorders, Augustana College, Rock Island, IL
  • Sheryl D. Hall
    Waisman Center, University of Wisconsin–Madison
  • Heather B. Karlsson
    Waisman Center, University of Wisconsin–Madison
  • Heather L. Mabie
    Waisman Center, University of Wisconsin–Madison
  • Jane L. McSweeny
    Waisman Center, University of Wisconsin–Madison
  • Christie M. Tilkens
    Waisman Center, University of Wisconsin–Madison
  • David L. Wilson
    Waisman Center, University of Wisconsin–Madison
  • Disclosure: The authors have declared that no competing interests existed at the time of publication.
    Disclosure: The authors have declared that no competing interests existed at the time of publication. ×
  • Correspondence to Lawrence D. Shriberg: shriberg@waisman.wisc.edu
  • Editor and Associate Editor: Julie Liss
    Editor and Associate Editor: Julie Liss×
Article Information
Speech, Voice & Prosodic Disorders / Apraxia of Speech & Childhood Apraxia of Speech / Research Issues, Methods & Evidence-Based Practice / Supplement: A Diagnostic Marker to Discriminate Childhood Apraxia of Speech from Speech Delay
Supplement Article   |   April 14, 2017
A Diagnostic Marker to Discriminate Childhood Apraxia of Speech From Speech Delay: II. Validity Studies of the Pause Marker
Journal of Speech, Language, and Hearing Research, April 2017, Vol. 60, S1118-S1134. doi:10.1044/2016_JSLHR-S-15-0297
History: Revised April 12, 2016 , Accepted August 21, 2016 , Received August 24, 2016
 
Journal of Speech, Language, and Hearing Research, April 2017, Vol. 60, S1118-S1134. doi:10.1044/2016_JSLHR-S-15-0297
History: Revised April 12, 2016; Accepted August 21, 2016; Received August 24, 2016
Web of Science® Times Cited: 3

Purpose The purpose of this 2nd article in this supplement is to report validity support findings for the Pause Marker (PM), a proposed single-sign diagnostic marker of childhood apraxia of speech (CAS).

Method PM scores and additional perceptual and acoustic measures were obtained from 296 participants in cohorts with idiopathic and neurogenetic CAS, adult-onset apraxia of speech and primary progressive apraxia of speech, and idiopathic speech delay.

Results Adjusted for questionable specificity disagreements with a pediatric Mayo Clinic diagnostic standard, the estimated sensitivity and specificity, respectively, of the PM were 86.8% and 100% for the CAS cohort, yielding positive and negative likelihood ratios of 56.45 (95% confidence interval [CI]: [1.15, 2763.31]) and 0.13 (95% CI [0.06, 0.30]). Specificity of the PM for 4 cohorts totaling 205 participants with speech delay was 98.5%.

Conclusion These findings are interpreted as providing support for the PM as a near-conclusive diagnostic marker of CAS.

Acknowledgments
This research was supported by National Institute on Deafness and Other Communication Disorders Grant DC000496, awarded to Lawrence D. Shriberg, and by a core grant, National Institute of Child Health and Development Grant HD03352, to the Waisman Center. The sixth and ninth authors made the original and substantial continuing contributions that led to the development of the Pause Marker. We are grateful to the following colleagues and collaborators for their significant contributions to this research: Len Abbeduto, Nancy Alarcon, Becky Baas, Adriane Baylis, Richard Boada, Roger Brown, Stephen Camarata, Thomas Campbell, Richard Folsom, Lisa Freebairn, Jordan Green, Barbara Lewis, Christopher Moore, Katherine Odell, Bruce Pennington, Nancy Potter, Jonathan Preston, Erin Redle, Heather Leavy Rusiewicz, Alison Scheer-Cohen, Kristie Spencer, Ruth Stoeckel, Bruce Tomblin, Jennifer Vannest, and Emily White. We also thank the many participants, parents of participants, and research colleagues who have contributed insights into the needs and issues in diagnostic research in childhood apraxia of speech.
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