Patient-Reported Measures of Hearing Loss and Tinnitus in Pediatric Cancer and Hematopoietic Stem Cell Transplantation: A Systematic Review Purpose We identified studies that described use of any patient-reported outcome scale for hearing loss or tinnitus among children and adolescents and young adults (AYAs) with cancer or hematopoietic stem cell transplantation (HSCT) recipients. Method In this systematic review, we performed electronic searches of OvidSP MEDLINE, EMBASE, and ... Review Article
Review Article  |   October 01, 2016
Patient-Reported Measures of Hearing Loss and Tinnitus in Pediatric Cancer and Hematopoietic Stem Cell Transplantation: A Systematic Review
 
Author Affiliations & Notes
  • Daniel Stark
    Section of Oncology and Cancer Research, Leeds Institute of Molecular Medicine, University of Leeds, United Kingdom
  • Abby R. Rosenberg
    Hematology/Oncology, Seattle Children's Hospital, WA
  • Donna Johnston
    Division of Paediatric Haematology/Oncology, Children's Hospital of Eastern Ontario, Ottawa, Canada
  • Kristin Knight
    Pediatric Audiology, Oregon Health and Science University, Portland
  • Lizzie Caperon
    Scholarly Communications and Researcher Skills, University of Leeds, United Kingdom
  • Elizabeth Uleryk
    E. M. Uleryk Consulting, Toronto, Ontario, Canada
  • A. Lindsay Frazier
    Dana-Farber/Boston Children's Cancer Center, MA
  • Lillian Sung
    Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
  • Disclosure: The authors have declared that no competing interests existed at the time of publication.
    Disclosure: The authors have declared that no competing interests existed at the time of publication. ×
  • Correspondence to Lillian Sung: lillian.sung@sickkids.ca
  • Editor: Nancy Tye-Murray
    Editor: Nancy Tye-Murray×
  • Associate Editor: Todd Ricketts
    Associate Editor: Todd Ricketts×
Article Information
Hearing Disorders / Hearing / Review Article
Review Article   |   October 01, 2016
Patient-Reported Measures of Hearing Loss and Tinnitus in Pediatric Cancer and Hematopoietic Stem Cell Transplantation: A Systematic Review
Journal of Speech, Language, and Hearing Research, October 2016, Vol. 59, 1247-1252. doi:10.1044/2016_JSLHR-H-15-0363
History: Received October 22, 2015 , Revised December 4, 2015 , Accepted January 4, 2016
 
Journal of Speech, Language, and Hearing Research, October 2016, Vol. 59, 1247-1252. doi:10.1044/2016_JSLHR-H-15-0363
History: Received October 22, 2015; Revised December 4, 2015; Accepted January 4, 2016

Purpose We identified studies that described use of any patient-reported outcome scale for hearing loss or tinnitus among children and adolescents and young adults (AYAs) with cancer or hematopoietic stem cell transplantation (HSCT) recipients.

Method In this systematic review, we performed electronic searches of OvidSP MEDLINE, EMBASE, and PsycINFO to August 2015. We included studies if they used any patient-reported scale of hearing loss or tinnitus among children and AYAs with cancer or HSCT recipients. Only English language publications were included. Two reviewers identified studies and abstracted data.

Results There were 953 studies screened; 6 met eligibility criteria. All studies administered hearing patient-reported outcomes only once, after therapy completion. None of the studies described the psychometric properties of the hearing-specific component. Three instruments (among 6 studies) were used: Health Utilities Index (Barr et al., 2000; Fu et al., 2006; Kennedy et al., 2014), Hearing Measurement Scales (Einar-Jon et al., 2011; Einarsson et al., 2011), and the Tinnitus Questionnaire for Auditory Brainstem Implant (Soussi & Otto, 1994). All had limitations, precluding routine use for hearing assessment in this population.

Conclusions We identified few studies that included hearing patient-reported measures for children and AYA cancer and HSCT patients. None are ideal to take forward into future studies. Future work should focus on the creation of a new psychometrically sound instrument for hearing outcomes in this population.

Acknowledgments
The first, second, third, and eighth authors conceptualized and designed the study; the first and eighth authors collected and analyzed the data and wrote the manuscript; and all authors critically revised the manuscript for important content. All authors approved the final version of the manuscript. The seventh author is a consultant for Decibel Therapeutics.
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