Is There a Role for Exercise in the Management of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis? Purpose The role of exercise in the management of people with amyotrophic lateral sclerosis (PALS) is controversial and currently unclear. The purpose of this review article is to review literature examining the impact of limb, respiratory, and oral motor exercise on function, disease progression, and survival in PALS and the ... Review Article
Review Article  |   August 01, 2015
Is There a Role for Exercise in the Management of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis?
 
Author Affiliations & Notes
  • Emily K. Plowman
    University of Florida, Gainesville
    Neuromotor Speech and Swallowing Restoration Laboratory, University of Florida, Gainesville
  • Disclosure: The author has declared that no competing interests existed at the time of publication.
    Disclosure: The author has declared that no competing interests existed at the time of publication. ×
  • Correspondence to Emily K. Plowman: eplowman@phhp.ufl.edu
  • Editor: Jody Kreiman
    Editor: Jody Kreiman×
  • Associate Editor: Caryn Easterling
    Associate Editor: Caryn Easterling×
Article Information
Speech, Voice & Prosodic Disorders / Swallowing, Dysphagia & Feeding Disorders / Special Populations / Speech, Voice & Prosody / Speech / Review Article
Review Article   |   August 01, 2015
Is There a Role for Exercise in the Management of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis?
Journal of Speech, Language, and Hearing Research, August 2015, Vol. 58, 1151-1166. doi:10.1044/2015_JSLHR-S-14-0270
History: Received September 30, 2014 , Revised February 24, 2015 , Accepted June 5, 2015
 
Journal of Speech, Language, and Hearing Research, August 2015, Vol. 58, 1151-1166. doi:10.1044/2015_JSLHR-S-14-0270
History: Received September 30, 2014; Revised February 24, 2015; Accepted June 5, 2015
Web of Science® Times Cited: 2

Purpose The role of exercise in the management of people with amyotrophic lateral sclerosis (PALS) is controversial and currently unclear. The purpose of this review article is to review literature examining the impact of limb, respiratory, and oral motor exercise on function, disease progression, and survival in PALS and the transgenic ALS animal model.

Method A literature review was conducted to examine relevant studies published in peer-reviewed journals between 1960 and 2014. All studies were appraised for quality of research and were assigned a level of evidence, and treatment outcomes were classified as either positive, negative, or neutral.

Results A total of 18 exercise-based intervention studies on limb (13), respiratory (3), or speech (2) function were identified. Of the human clinical trials, 6 were experimental and 4 were exploratory. No experimental studies were identified examining the impact of targeted exercise on speech or swallowing function. Mild to moderate intensity limb or respiratory exercise, applied early in the disease, was noted to have a beneficial impact on motor function and survival.

Conclusion Insufficient data exist to support or refute the role of exercise in the management of bulbar dysfunction in PALS. This represents a critical area of future investigation.

Acknowledgments
The author wishes to acknowledge and thank Dr. Ianessa Humbert and Dr. Jay Rosenbek for commentary on earlier versions on this article as well as the reviewers and editors for thoughtful suggestions that improved the quality of this article.
Order a Subscription
Pay Per View
Entire Journal of Speech, Language, and Hearing Research content & archive
24-hour access
This Article
24-hour access