The Effects of Hyper- and Hypocapnia on Phonatory Laryngeal Airway Resistance in Women Purpose The larynx has a dual role in the regulation of gas flow into and out of the lungs while also establishing resistance required for vocal fold vibration. This study assessed reciprocal relations between phonatory functions—specifically, phonatory laryngeal airway resistance (Rlaw)—and respiratory homeostasis during states of ventilatory gas perturbations. ... Research Article
Research Article  |   June 01, 2015
The Effects of Hyper- and Hypocapnia on Phonatory Laryngeal Airway Resistance in Women
 
Author Affiliations & Notes
  • Amanda I. Gillespie
    University of Pittsburgh Voice Center, University of Pittsburgh Medical Center, PA
    University of Pittsburgh, PA
  • William Slivka
    University of Pittsburgh Medical Center, PA
  • Charles W. Atwood, Jr.
    University of Pittsburgh Medical Center, PA
  • Katherine Verdolini Abbott
    University of Pittsburgh, Center for the Neural Basis of Cognition, PA
    McGowan Institute for Regenerative Medicine, Carnegie Mellon University, Pittsburgh, PA
  • Disclosure: The authors have declared that no competing interests existed at the time of publication.
    Disclosure: The authors have declared that no competing interests existed at the time of publication.×
  • Correspondence to Amanda I. Gillespie: gillespieai@upmc.edu
  • Editor: Jody Kreiman
    Editor: Jody Kreiman×
  • Associate Editor: Bruce Gerratt
    Associate Editor: Bruce Gerratt×
Article Information
Speech, Voice & Prosody / Speech / Research Articles
Research Article   |   June 01, 2015
The Effects of Hyper- and Hypocapnia on Phonatory Laryngeal Airway Resistance in Women
Journal of Speech, Language, and Hearing Research, June 2015, Vol. 58, 638-652. doi:10.1044/2015_JSLHR-S-13-0270
History: Received October 1, 2013 , Revised May 16, 2014 , Accepted February 11, 2015
 
Journal of Speech, Language, and Hearing Research, June 2015, Vol. 58, 638-652. doi:10.1044/2015_JSLHR-S-13-0270
History: Received October 1, 2013; Revised May 16, 2014; Accepted February 11, 2015
Web of Science® Times Cited: 2

Purpose The larynx has a dual role in the regulation of gas flow into and out of the lungs while also establishing resistance required for vocal fold vibration. This study assessed reciprocal relations between phonatory functions—specifically, phonatory laryngeal airway resistance (Rlaw)—and respiratory homeostasis during states of ventilatory gas perturbations.

Method Twenty-four healthy women performed phonatory tasks while exposed to induced hypercapnia (high CO2), hypocapnia (low CO2), and normal breathing (eupnea). Effects of gas perturbations on Rlaw were investigated as were the reciprocal effects of Rlaw modulations on respiratory homeostasis.

Results Rlaw remained stable despite manipulations of inspired gas concentrations. In contrast, end-tidal CO2 levels increased significantly during all phonatory tasks. Thus, for the conditions tested, Rlaw did not adjust to accommodate ventilatory needs as predicted. Rather, stable Rlaw was spontaneously accomplished at the cost of those needs.

Conclusions Findings provide support for a theory of regulation wherein Rlaw may be a control parameter in phonation. Results also provide insight into the influence of phonation on respiration. The work sets the foundation for future studies on laryngeal function during phonation in individuals with lower airway disease and other patient populations.

Acknowledgments
This research was supported by National Institute on Deafness and Other Communication Disorders Grant F31 DC012707 to Amanda I. Gillespie. The authors would also like to acknowledge Kaleab Abebe, Leah Helou, Aaron Ziegler, and Frank Sciurba for their invaluable assistance.
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