Fundamental Approaches in Molecular Biology for Communication Sciences and Disorders PurposeThis contemporary tutorial will introduce general principles of molecular biology, common deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and protein assays and their relevance in the field of communication sciences and disorders.MethodOver the past 2 decades, knowledge of the molecular pathophysiology of human disease has increased at a remarkable pace. Most ... Tutorial
Tutorial  |   August 01, 2012
Fundamental Approaches in Molecular Biology for Communication Sciences and Disorders
 
Author Affiliations & Notes
  • Marie E. Jetté
    University of Wisconsin—Madison
  • Suzanne N. King
    University of Wisconsin—Madison
  • Allison Schaser
    University of Wisconsin—Madison
  • Susan L. Thibeault
    University of Wisconsin—Madison
  • Correspondence to Rebecca S. Bartlett: bartlett@surgery.wisc.edu
  • Editor and Associate Editor: Anne Smith
    Editor and Associate Editor: Anne Smith×
Article Information
Special Populations / Genetic & Congenital Disorders / Speech
Tutorial   |   August 01, 2012
Fundamental Approaches in Molecular Biology for Communication Sciences and Disorders
Journal of Speech, Language, and Hearing Research, August 2012, Vol. 55, 1220-1231. doi:10.1044/1092-4388(2011/11-0152)
History: Received June 14, 2011 , Revised October 24, 2011 , Accepted December 16, 2011
 
Journal of Speech, Language, and Hearing Research, August 2012, Vol. 55, 1220-1231. doi:10.1044/1092-4388(2011/11-0152)
History: Received June 14, 2011; Revised October 24, 2011; Accepted December 16, 2011

PurposeThis contemporary tutorial will introduce general principles of molecular biology, common deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and protein assays and their relevance in the field of communication sciences and disorders.

MethodOver the past 2 decades, knowledge of the molecular pathophysiology of human disease has increased at a remarkable pace. Most of this progress can be attributed to concomitant advances in basic molecular biology and, specifically, the development of an ever-expanding armamentarium of technologies for analysis of DNA, RNA, and protein structure and function. Details of these methodologies, their limitations, and examples from the communication sciences and disorders literature are presented.

Results/ConclusionsThe use of molecular biology techniques in the fields of speech, language, and hearing sciences is increasing, facilitating the need for an understanding of molecular biology fundamentals and common experimental assays.

Acknowledgments
This work was sponsored by National Institute on Deafness and Other Communication Disorders Grants R01 DC4336, R01 DC9600, R01 DC008149, and T32 DC009401. We acknowledge Gary Weismer for his encouragement and the original tutorial conception.
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