Pitch Variability in Patients With Parkinson’s Disease: Effects of Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus PurposeThe purpose of the present study was to examine the effect of deep brain stimulation (DBS) of the subthalamic nucleus (STN) and the caudal zona incerta (cZi) pitch characteristics of connected speech in patients with Parkinson’s disease (PD).MethodThe authors evaluated 16 patients preoperatively and 12 months after DBS surgery. Eight ... Article
Article  |   February 01, 2013
Pitch Variability in Patients With Parkinson’s Disease: Effects of Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus
 
Author Affiliations & Notes
  • Fredrik Karlsson
    Umeå University, Umeå, Sweden
  • Katarina Olofsson
    Umeå University, Umeå, Sweden
  • Patric Blomstedt
    Umeå University, Umeå, Sweden
  • Jan Linder
    Umeå University, Umeå, Sweden
  • Jan van Doorn
    Umeå University, Umeå, Sweden
  • Correspondence to Fredrik Karlsson: fredrik.karlsson@ling.umu.se
  • Editor: Jody Kreiman
    Editor: Jody Kreiman×
  • Associate Editor: Anne-Maria Laukkanen
    Associate Editor: Anne-Maria Laukkanen×
Article Information
Speech, Voice & Prosodic Disorders / Special Populations / Older Adults & Aging / Speech
Article   |   February 01, 2013
Pitch Variability in Patients With Parkinson’s Disease: Effects of Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus
Journal of Speech, Language, and Hearing Research, February 2013, Vol. 56, 150-158. doi:10.1044/1092-4388(2012/11-0333)
History: Received December 1, 2011 , Revised April 16, 2012 , Accepted June 3, 2012
 
Journal of Speech, Language, and Hearing Research, February 2013, Vol. 56, 150-158. doi:10.1044/1092-4388(2012/11-0333)
History: Received December 1, 2011; Revised April 16, 2012; Accepted June 3, 2012
Web of Science® Times Cited: 1

PurposeThe purpose of the present study was to examine the effect of deep brain stimulation (DBS) of the subthalamic nucleus (STN) and the caudal zona incerta (cZi) pitch characteristics of connected speech in patients with Parkinson’s disease (PD).

MethodThe authors evaluated 16 patients preoperatively and 12 months after DBS surgery. Eight patients were implanted in the STN (ages 51–72 years; M = 63 years). Six received bilateral implantation and 2 unilateral (left) implantation. Eight patients were bilaterally implanted in the cZi (ages 49–71 years; M = 60.8 years). Preoperative assessments were made after a levodopa challenge (approximately 1.5 times the ordinary dose). All postoperative examinations were made off and on stimulation with a clinically optimized dose of levodopa. Measurements of pitch range and variability were obtained from each utterance in a recorded read speech passage.

ResultsPitch range and coefficient of variation showed an increase in patients under STN–DBS. Patients under cZi–DBS showed no significant effects of treatment on investigated pitch properties.

ConclusionSTN–DBS was shown to increase pitch variation and range. The results provided no evidence of cZi–DBS having a beneficial effect on PD patients' pitch variability.

Acknowledgments
We wish to acknowledge the support of Grant 2009-946 from the Swedish Research Council and Parkinson Foundation in Sweden. We would like to thank DBS nurse specialist Anna Fredricks for assistance in providing patient information and research engineer Anders Asplund for preparation of the speech recordings.
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