Preliminary Voice and Speech Analysis Following Fetal Dopamine Transplants in 5 Individuals With Parkinson Disease A surgical procedure involving transplantation of fetal dopamine cells into the striatum of persons with advanced Parkinson disease (PD) has recently been performed in an attempt to alleviate Parkinsonian and drug-dose related symptoms (e.g., the “on-off” phenomena). Improvements in limb motor and neurological function, as well as less severe and ... Research Article
Research Article  |   June 01, 1997
Preliminary Voice and Speech Analysis Following Fetal Dopamine Transplants in 5 Individuals With Parkinson Disease
 
Author Affiliations & Notes
  • Kristin K. Baker
    The Wilbur James Gould Voice Research Center The Denver Center for the Performing Arts Denver, CO
  • Lorraine Olson Ramig
    Department of Communication Disorders and Speech Science University of Colorado-Boulder and The Wilbur James Gould Voice Research Center The Denver Center for the Performing Arts Denver, CO
  • Antonia B. Johnson
    The Wilbur James Gould Voice Research Center The Denver Center for the Performing Arts Denver, CO
  • Curt R. Freed
    University of Colorado Health Sciences Center Denver, CO
  • Corresponding author: e-mail: kristin@star.dcpa.org
Article Information
Special Populations / Older Adults & Aging / Speech, Voice & Prosody / Speech / Research Articles
Research Article   |   June 01, 1997
Preliminary Voice and Speech Analysis Following Fetal Dopamine Transplants in 5 Individuals With Parkinson Disease
Journal of Speech, Language, and Hearing Research, June 1997, Vol. 40, 615-626. doi:10.1044/jslhr.4003.615
History: Received April 4, 1996 , Accepted December 5, 1996
 
Journal of Speech, Language, and Hearing Research, June 1997, Vol. 40, 615-626. doi:10.1044/jslhr.4003.615
History: Received April 4, 1996; Accepted December 5, 1996

A surgical procedure involving transplantation of fetal dopamine cells into the striatum of persons with advanced Parkinson disease (PD) has recently been performed in an attempt to alleviate Parkinsonian and drug-dose related symptoms (e.g., the “on-off” phenomena). Improvements in limb motor and neurological function, as well as less severe and shorter on-off episodes have been reported following fetal cell transplant (FCT) surgery. Acoustic, electroglottographic, and perceptual measures were analyzed pre- and post-surgery to determine if phonatory and articulatory function were affected by this relatively new form of treatment. In addition, speech and motor exam measures were compared to determine if similar directional changes across motor systems were apparent. Findings suggest that FCT surgery did not systematically influence voice and speech production. Also, it appears that FCT surgery may differentially affect phonatory, articulatory, and limb motor systems. Findings are discussed relative to these differential effects.

Acknowledgment
This research was supported in part by grants NIHNIDCD #P60 DC00976-06 and R01 DC01150.
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