Genetic Aspects of Early Childhood Stuttering Although stuttering has long been acknowledged as a familial disorder, the nature of a genetic component remains unclear. Most previous data used in genetic studies were obtained primarily from adults who stutter and may be biased in several respects. The purpose of this investigation was to quantify the frequency of ... Research Article
Research Article  |   August 1993
Genetic Aspects of Early Childhood Stuttering
 
Author Affiliations & Notes
  • Nicoline Grinager Ambrose
    University of Illinois at Urbana-Champaign
  • Ehud Yairi
    University of Illinois at Urbana-Champaign
  • Nancy Cox
    Department of Medicine, University of Chicago
  • Contact author: Nicoline Ambrose, University of Illinois, Speech and Hearing Science, 901 South Sixth Street, Champaign, IL 61820.
Article Information
Speech, Voice & Prosodic Disorders / Fluency Disorders / Special Populations / Genetic & Congenital Disorders / Speech / Research Articles
Research Article   |   August 1993
Genetic Aspects of Early Childhood Stuttering
Journal of Speech, Language, and Hearing Research, August 1993, Vol. 36, 701-706. doi:10.1044/jshr.3604.701
History: Received July 27, 1992 , Accepted April 9, 1993
 
Journal of Speech, Language, and Hearing Research, August 1993, Vol. 36, 701-706. doi:10.1044/jshr.3604.701
History: Received July 27, 1992; Accepted April 9, 1993

Although stuttering has long been acknowledged as a familial disorder, the nature of a genetic component remains unclear. Most previous data used in genetic studies were obtained primarily from adults who stutter and may be biased in several respects. The purpose of this investigation was to quantify the frequency of stuttering in relatives of preschool-age children who stutter, and who were first seen close to the onset of the disorder. Detailed pedigrees (family trees), including first-, second-, and third-degree relatives, were obtained from parents of 69 children who stuttered. We found, as have previous studies, that more male than female relatives ever stuttered, but that female subjects who stuttered had more female relatives who ever stuttered than did male subjects. In order to identify the genetic model most consistent with the observed patterns of stuttering transmission, we conducted segregation analyses. Results from these analyses suggest that transmission of a single major genetic locus increasing the liability to stuttering best accounts for the transmission of stuttering in families of preschool-age children who stutter.

Acknowledgments
This study was supported by grant #R01-DC00459 from the National Institute of Deafness and Other Communication Disorders. Ehud Yairi was the principal investigator.
Order a Subscription
Pay Per View
Entire Journal of Speech, Language, and Hearing Research content & archive
24-hour access
This Article
24-hour access